SHOCKING scans have revealed a major clue that could help solve the ongoing mystery of why certain people experience debilitating migraines.
MRI images show people who suffer with the painful condition have enlarged fluid-filled spaces surrounding blood vessels in central regions of the brain.
US researchers believe this could suggest these people have problems flushing waste from the brain and the nervous system.
A migraine is usually characterised by a moderate or severe headache felt as a throbbing pain on one side of the head.
Around 10 million people aged 15-69 in the UK suffer from the condition, which costs the NHS around £400million each year, estimates suggest.
The cost to the wider economy is even higher, with around £4.4billion a year lost to three million migraine-related sick days, according to NHS England.
Wilson Xu of the University of Southern California in Los Angeles, US said: “In people with chronic migraine and episodic migraine without aura, there are significant changes in the perivascular spaces of a brain region called the centrum semiovale.
“These changes have never been reported before.”
Although the nature of the link between oversized perivascular spaces and migraine is unclear, the results suggest that a migraine comes with a problem with the brain’s plumbing, the researchers explained.
This is because the brain’s waste emptying process, known as the glymphatic system, uses perivascular channels for transport.
“The results of our study could help inspire future, larger-scale studies to continue investigating how changes in the brain’s microscopic vessels and blood supply contribute to different migraine types,” Prof Wilson said.
“Eventually, this could help us develop new, personalised ways to diagnose and treat migraine.”
The latest study looked at the brains of 25 people aged between 25 and 60 years old.
All were healthy and did not have a cognitive impairments or mental health conditions.
Some had frequent migraines, others reported occasional migraines and others reported no symptoms at all.
All of the participants underwent a high resolution brain scan known as a 7T scan, which produces higher resolution images than an MRI.
Results showed migraine sufferers had significantly more enlarged perivascular spaces than those who had never experienced the condition.
Results of the study will be presented next week at the annual meeting of the Radiological Society of North America, in Chicago, US.
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